2021-03-22
郭众，生物科技研究中心副教授，博士生导师
E-mail：z.guo@bnu.edu.cn
研究领域
合成生物学：工程化改造底盘细胞是合成生物学领域重要的研究内容，实验室将长期致力于改造不同底盘细胞，应用于肿瘤、细菌感染疾病和代谢性疾病的治疗。
纳米医学：多功能纳米递送系统在疾病精准治疗中发挥重要作用，实验室通过开发免疫相关细胞靶向型多功能纳米佐剂制备纳米疫苗，用于肿瘤和细菌感染疾病的防治。
学习工作经历
2021.02-至今 北京师范大学 珠海校区，副教授，硕士/博士生导师
2020.03-2021.01 苏黎世联邦理工学院 博士后 （Martin Fussenegger）
2017.12-2019.12 南洋理工大学 博士后 （Xue-Wei Liu）
2014.09-2017.06 暨南大学，博士
2011.09-2014.06 暨南大学，硕士
2007.09-2011.06 西北农林科技大学，学士
代表论文
You-Bo Yu, Ying Liu, Hangeri Liang, Xianxin Dong, Sha Li*, Xiao-Yan Yang*, Zhong Guo*. A Nanoparticle-based Anti-Caries Vaccine Enhances the Persistent Immune Response to Inhibit Streptococcus mutans and Prevent Caries. Microbiology Spectrum. 2023 Mar 28:e0432822.
You-Bo Yu, Ying Liu, Sha Li, Xiao-Yan Yang*, Zhong Guo*. The pH-responsive zeolitic imidazolate framework nanoparticle as a promising immune-enhancing adjuvant for anti-caries vaccine. Journal of Dentistry. 2023, 130, 104413.
Yunxi Du, Zhong Guo*. Recent progress in ferroptosis: inducers and inhibitors. Cell Death & Discovery. 2022. Dec. 19.
Xin Cao#; Zhong Guo#; Hualong Wang; Yuelei Dong; Songhui Lu; Qing-Yu He*; Xuesong Sun*; Gong Zhang*. Autoactivation of translation causes the bloom of Prorocentrum Donghainese in harmful algal blooms. Journal of Proteome Research., 2021, 20(6):3179-3187.
Zhong Guo, Sha Li, Yangchun Qu, Wei Xue, Xifei Yu*, Zonghua Liu*. Bio-membrane adhesive poly(choline phosphate L-glutamate)-based nanoparticles as vaccine delivery systems for cancer immunotherapy. Chemical Engineering Journal., 2021, 417, 127970.
Zhong Guo, Jingxi He, Surendra H. Mahadevegowda, Kho Shu Hui, Mary B. Chan-Park*, and Xuewei Liu*. Multifunctional Glyco-Nanosheets to Eradicate Drug-Resistant Bacteria on Wounds. Advanced Healthcare Materials., 2020, 9(10), 202000265.
Zhong Guo, Sha Li, Zonghua Liu*, Wei Xue*. Tumor-Penetrating Peptide-Functionalized Redox-Responsive Hyperbranched Poly(amido amine) Delivering siRNA for Lung Cancer Therapy. ACS Biomaterial Science & Engineering., 2018, 4(3), 988-996.
Meng Lv, Sha Li, Haijie Zhao, Kewei Wang, Qianqian Chen, Zhong Guo*, Zonghua Liu* and Wei Xue*. Redox-responsive hyperbranched poly(amido amine) and polymer dots as a vaccine delivery system for cancer immunotherapy. Journal of Materials Chemistry B., 2017, 5, 9532-9545.
Zhong Guo#, Sha Li#, Zonghua Liu*, and Wei Xue*. Redox-responsive biodegradable PAA used for intranasal antigen delivery systems. ACS Biomaterial Science & Engineering., 2017, 3 (10), 2420–2430.
Sha Li#, Zhong Guo#, Wei Xue, and Zonghua Liu*. Hyperbranched polyglycerol conjugated fluorescent carbon dots with improved biocompatibility for bioimaging. RSC Advance., 2017, 7, 4975-4982.
Zhong Guo, Sha Li, Changyong Wang, Jiake Xu, Brett Kirk, Jianping Wu, Zonghua Liu*, and Wei Xue*. Biocompatibility and cellular uptake mechanisms of poly(N-isopropylacrylamide) in different cells. Journal of Bioactive and Compatible Polymers., 2017, 32(1), 17-31.
Zhong Guo, JunLong Han, XiaoYan Yang, Kun Cao, Ke He, GaoFei Du, GuanDi Zeng, Liang Zhang, GuangChuang Yu, ZhengHua Sun, QingYu He*, XueSong Sun*. Proteomic analysis of the copper resistance of Streptococcus pneumoniae. Metallomics., 2015, 7(3), 448-54
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